what could potentially cause more damage (or a greater benefit) to an organism, a deletion mutation at the beginning of a dna sequence or at the end of a dna sequence?

Answers

Answer 1

A deletion mutation at the beginning of a dna sequence could potentially cause more damage to an organism.

Changing an organism's DNA sequence is known as a mutation. An infection with a virus, exposure to mutagens, or mistakes in DNA replication during cell division can all cause mutations. The nucleic acid sequence of an organism's, virus's, or extrachromosomal DNA can change due to a mutation. RNA or DNA make up viral genomes.

Any organic, living system that acts independently of other systems is referred to as an organism. There are cells in every living thing. Animals, plants, and fungi with many cells, as well as protists, bacteria, and archaea, are some examples of the taxonomically categorised groupings into which organisms fall. Any organic, living system that acts independently of other systems is referred to as an organism.

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Related Questions

.Which of the following animals does NOT have a body cavity? See Concept 32.3 (Page 678)
earthworm
mouse
clam
flatworm
nematode

Answers

Flatworms, also known as Platyhelminthes, do not have a body cavity.

Flatworms are a group of invertebrate animals that have flattened, ribbon-like bodies with no internal body cavity other than a gut cavity. They lack a coelom, which is a fluid-filled cavity that is completely lined with mesoderm tissue and is present in most other animal phyla.

Earthworms, mice, clams, and nematodes all have a body cavity, either a true coelom or a pseudocoelom. The coelom or pseudocoelom serves important functions in these animals, such as providing a space for internal organs to be suspended, allowing for movement and flexibility, and acting as a hydrostatic skeleton in some species.

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Can someone please help me on this!! It’s due for my next class Will give brainliest and a heart if completed with the 4 questions!

Can someone please help me on this!! Its due for my next class Will give brainliest and a heart if completed

Answers

Answer:

1. Homeostasis the internal regulation of the body. Keeps everything at the factory setting if you will.

2. Homeostasis is all about balance which is similar to a cell membrane in that the cell membrane will only allow certain particles to pass in order to balance salt and water concentration.

3. Endotherms experience homeostasis while ectotherms do not. Ectotherms are “cold blooded” and need to use external resources to warm and cool their body.

4. Negative feedback is a key part in homeostasis in that it helps signal the body to balance something out. Example: when it’s cold you shiver and when it’s hot you sweat. Both are examples of negative feedback.

Explanation:

Need some help figuring out the basis of this
Demonstrate your understanding of marine plankton, microbes, plants, and algae by creating two job postings or resumes. These should include how those organisms are important to their ecosystems. See the assignment details for further instructions.

Answers

Scientists classify plankton in several ways, including by size, type, and how long they spend drifting. But the most basic categories divide plankton into two groups: phytoplankton (plants) and zooplankton (animals)

How are soluble food molecules absorbed into the epithelial cells of the small intestine

Answers

Soluble food molecules are absorbed into the epithelial cells of the small intestine through the process of diffusion and active transport.

best defines homeostasis

Answers

Sentence:

The skill of keeping internal stability in an organism to regroup for environment changes

Word/Synonym:

Equilibrium

Write a question using the words COMPETITION and SURVIVE. *

Answers

Q. What is the competition among SPECIES (intra, and Inter)? And how it help will to SURVIVE?

While making the question we should always relate the main term or concept with the other situation which may be of same type or different. The concept should be clear by using more technical words, as well as idea of the question which candidate have to answer. The use of more grammar is also play important role, like the correct use of grammar at correct place provide the clarity of the question, but it may also confuse the candidate. For more clarity, always ask examples, or case study which candidates have to answer.

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by producing vast amounts of compost annually, this facility in edmonton focuses on wasteprevention in dealing with solid waste, as represented by thegreen (b) arrows in the preceding flowchart.

Answers

The facility in Edmonton focuses on waste prevention through the annual production of vast amounts of compost.

The facility in Edmonton takes a proactive approach to solid waste management by emphasizing waste prevention through the production of compost. Composting is a natural process that transforms organic waste materials into nutrient-rich soil amendment. By diverting organic waste from landfills and converting it into compost, the facility contributes to reducing the overall volume of solid waste generated in the area.

Composting offers several environmental benefits. Firstly, it helps to decrease the amount of waste being sent to landfills, which helps to extend the lifespan of these facilities and reduces the need for new ones. Additionally, composting organic waste prevents the release of harmful greenhouse gases, such as methane, which are generated when organic matter decomposes in landfills. By diverting organic waste to the composting facility, these greenhouse gas emissions are significantly reduced, contributing to mitigating climate change.

Furthermore, the compost produced at the facility serves as a valuable resource for soil enrichment. The nutrient-rich compost can be used in agriculture, horticulture, and landscaping, improving soil health, water retention, and overall plant growth. By utilizing compost, farmers and gardeners can reduce their reliance on synthetic fertilizers, which can have negative environmental impacts.

Overall, the facility in Edmonton plays a vital role in waste prevention and sustainable solid waste management by focusing on the production of vast amounts of compost. This approach reduces landfill waste, mitigates greenhouse gas emissions, and provides a valuable resource for soil enrichment.

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Some cells have structures called chloroplasts, which contain the green pigment chlorophyll.

a) Explain the role of chloroplasts in these cells.

b) Name two things from the environment that chloroplasts must have to perform this
role.

Answers

Answer:

Chloroplasts convert light energy to chemical energy to supply food to the plant through a process called photosynthesis

Water and Sunlight

Any mutation can lead to cancer. True or False?
GIVE EXPLANATION. Will give brainliest ;D

Answers

I think so, because all cancer come from a type of mutation. So yes.

During the alarm stage of the body’s stress response, what emergency hormone is released to prepare the body to respond to a stressor?.

Answers

Answer:

Adrenaline

Explanation:

Adrenaline is a hormone that prepares the body for "fight or flight"

The chemical signals that travel from one neuron to another, enabling them to communicate with one another, are called:

Answers

Answer:

The chemical signal is called a neurotransmitter. Neurotransmitters allow the billions of neurons in the nervous system to communicate with one another.

Explanation:

How does the size of the prairie compare to other biomes? A:The prairie is much smaller in comparison to the desert biome. B:The prairie is only found in Midwest. C:The prairie is the only biome found in the United States. D:The prairie covers most of the United States.​

Answers

The size of the prairie in comparison to other biomes is the prairie is much smaller in comparison to the desert biome.

Therefore, option A is the correct answer.What is a biome?Biome refers to a large group of ecosystems characterized by specific climatic conditions and types of vegetation and wildlife. It is a community of plants and animals that have common characteristics for the environment they exist in. Some of the well-known biomes include rainforests, deserts, tundras, and grasslands.The prairie biomeThe prairie biome is characterized by tall grasses, wildflowers, and flat land. This biome has very fertile soil, a long growing season, and few trees, which makes it perfect for agricultural activities. It also has a semi-arid climate with moderate temperatures. The Great Plains of North America is an example of a prairie biome. It covers around 1.5 million square miles across the United States from Canada down to Texas. The prairie biome is also one of the smallest biomes globally. Therefore, the prairie is much smaller compared to the desert biome and other biomes.

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What two chromosomes do males have for gender?


Sperm cells do not contain sex chromosomes.


X chromosomes


X and Y chromosomes


Y chromosomes

Answers

X and Y chromosomes are two chromosomes the males have

Answer:

Yes X and Y chromosomes

Explanation:

Took Test (k-12 student lol)

A population has 1000 individuals. Over a period of 1 year, 300 new
individuals are born. Which equation shows how to calculate the birthrate of
this population?
A. 300 - 1000 = 0.3
B. 1000 + 300 = 1300
C. 1000 x 0.3 = 300
D. 1000 - 300 = 3.33

Answers

Answer:

ITS A!!!!!

Explanation:

APPPP333333XXXXX

The birth rate is defined as the number of births in a particular time divided by the total population. So the correct option is A.

What is the birth rate?

A total number of births in a specific time (a year) divided by the total population (usually taken as 1000) is called the birth rate. The birth rate is calculated for various reasons.

Some of the things for which birth rate is needed are population count, universal registration of births etc.

Population growth is calculated using birth rate, mortality rate and migration rate from a population. The mid-year population is usually taken as the estimated population.

The birth rate is also referred to as natality. The rate of natural increase is given when the crude death rate is subtracted from the crude birth rate.

The birth rate of a population should be maintained at a moderate level by providing resources to people with children, creating awareness about methods of contraception etc.

The birth rate is calculated by dividing the number of births by the total population.

Therefore the correct option is A.

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Similar fossil remains found on different continents give evidence for the theory of continental drift.
True
O False


HELLLLLLLP!!!!!!!!

Answers

Answer:

True

Explanation:

It just is lol

True
If you were to say you found one bone on one continent, and another one that looks just like it on another, it would either mean they were a common species or they were together at once but drifted apart

Which step in the development of cancer is the most dangerous?

Growth of tumor
Formation of tumor
Metastasis of cancer cells
Abnormal division of cells

Answers

The answer your looking for is b

Answer:

answer is b

Explanation:

Wheat ‘dough’ is derived from the grain

Answers

Wheat dough is indeed derived from the grain. The process involves combining wheat flour with water and sometimes other ingredients like yeast, salt, and sugar to form a pliable, elastic dough.

This dough is then shaped and baked into a variety of baked goods like bread, pastries, and pasta.

Wheat is the most commonly used grain for making dough due to its gluten content, which gives the dough its elasticity and helps it rise during baking. Dough made from wheat flour can be used to make a wide range of dishes and is a staple in many cuisines around the world.
Wheat dough is derived from the grain by combining ground wheat flour with water and sometimes other ingredients, such as yeast and salt.

The wheat grain consists of three main parts: the bran, the germ, and the endosperm. When milled, the endosperm is primarily used to create white flour, which is then used to make dough. Wheat dough is commonly utilized for baking various types of bread, pastries, and other baked goods. The process of kneading the dough helps to develop gluten, a protein present in wheat flour, which provides structure and elasticity to the final baked product.

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What is a reproductive strategy?

a.) The way that a species creates offspring b.)The way that an organism hunts for food c.)The number of alleles an organism passes on d.) The DNA that is passed onto an offspring

Answers

Answer:

I am pretty sure that the answer is (a) The way that a species creates offspring.

Explanation:

The term reproductive strategy is loosely used to refer to the way an animal mates and/or raises offspring.

Which hormones is produced in the stomach and stimulates hunger?

Answers

The hormone produced in the stomach that stimulates hunger is called ghrelin.

Ghrelin is primarily synthesized and released by specialized cells in the lining of the stomach, known as the gastric oxyntic cells or X/A-like cells.

Ghrelin plays a crucial role in regulating appetite and energy balance. Its levels in the bloodstream increase before meals and decrease after eating. This hormone acts on the hypothalamus, the region of the brain responsible for regulating hunger and satiety, to stimulate appetite and promote food intake.

When the stomach is empty, ghrelin is released into the bloodstream and binds to receptors in the hypothalamus, activating orexigenic (appetite-stimulating) pathways. This stimulates the release of neuropeptides, such as neuropeptide Y (NPY) and Agouti-related peptide (AgRP), which increase appetite and food-seeking behavior. Ghrelin also affects other brain regions involved in reward and motivation, further promoting food intake.

The secretion of ghrelin is influenced by various factors, including fasting, caloric restriction, stress, and sleep deprivation. Ghrelin levels tend to be higher in individuals with conditions like anorexia nervosa or during prolonged fasting, while they decrease after consuming a meal or in individuals who are overweight or obese.

In summary, ghrelin is the hormone produced in the stomach that stimulates hunger. Its release triggers appetite and food intake by acting on the hypothalamus and activating orexigenic pathways in the brain.

Understanding the role of ghrelin helps in elucidating the complex mechanisms involved in appetite regulation and may have implications for managing conditions related to appetite and body weight.

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Explain how form and function are related in human cells, including examples. Use at least five sentences in your answer. The shape of a cellular structure is related to the function they have perform
Compare and contrast epithelial and muscle tissues. Use at least three sentences in your answer. ​

Answers

Explanation:

Form and function are intimately related in human cells. The shape and structure of cellular components are often specifically designed to carry out their respective functions effectively. For example, red blood cells are disc-shaped with a concave center, which increases their surface area for efficient oxygen and carbon dioxide exchange. Neurons have long, branching extensions called dendrites and axons, allowing them to transmit electrical signals over long distances.

Epithelial tissues are composed of closely packed cells that form protective barriers and linings in the body. They cover external surfaces (such as the skin) and line internal organs and cavities (such as the digestive tract). In contrast, muscle tissues consist of cells that are specialized for contraction and movement. There are three types of muscle tissues: skeletal muscle, responsible for voluntary movements; cardiac muscle, found in the heart; and smooth muscle, which controls involuntary movements in organs like the intestines.

Epithelial tissues primarily function in protection, absorption, and secretion. They have tightly packed cells with minimal extracellular matrix. In contrast, muscle tissues are specialized for contraction and movement. They contain long, elongated cells (muscle fibers) that can generate force. Skeletal muscle is striated and allows for voluntary movements, while cardiac and smooth muscles have different structures and functions specific to their respective roles in the body.

In summary, the relationship between form and function is evident in human cells. Cellular structures are designed with specific shapes and arrangements to perform their functions efficiently. Epithelial tissues provide protective barriers and linings, while muscle tissues enable contraction and movement. Understanding the relationship between form and function helps us appreciate the intricate design of cells and tissues in the human body.

PLEASE HURRY!!!!! NEED HELP ASAP!!!!
Which physical adaptations increase a plant’s chances of growing in grasslands?
(Select all that apply.)
A. having deep roots to survive grazing animals
B. having leaf shapes that do not hold water
C. having waxy leaves
D. having deep roots to survive fires

Answers

Answer:

Explanation:

A. having deep roots to survive grazing animals

B. having leaf shapes that do not hold water

D. having deep roots to survive fires

Plants that grow in grasslands must be able to survive in a variety of conditions, including hot temperatures, dry conditions, and frequent fires. In order to do so, they have developed a number of physical adaptations that increase their chances of survival.

One adaptation that helps plants survive grazing animals is having deep roots. These roots can allow the plant to access water and nutrients that are deeper in the soil, which can help it survive even when the surface of the soil has been damaged by grazing animals.

Another adaptation that helps plants survive in grasslands is having leaf shapes that do not hold water. This can help prevent the plant from losing water through evaporation, which is especially important in hot and dry conditions.

Having deep roots can also help plants survive fires, as these roots can allow the plant to access water and nutrients that are deeper in the soil and help it regenerate after a fire.

While having waxy leaves can help some plants retain moisture in dry conditions, it is not necessarily an adaptation that is specific to grasslands.

Which of the following is a correct sequence of the flow of blood in a systemic circulation?
A. Heart →aorta →arteries → arterioles capillaries→ tissues → venules → veins → superior and inferior vena cava → heart
B. Heart → pulmonary artery → lungs → pulmonary veins → Heart
C. Heart → pulmonary veins → lungs → pulmonary artery → Heart
D. Heart → venules → veins → capillaries → tissues → Aorta → arteries → arterioles → superior and inferior vena cava → heart

Answers

Answer:

The correct option is A. Heart →aorta →arteries → arterioles capillaries→ tissues → venules → veins → superior and inferior vena cava → heart

What kind of stem cells are used to treat patients with heart attacks?
Kinds of stem cells: Tissue-specific, embryonic stem cell, adult, and etc.

Answers

Answer:

I've sent a pic for answers

What kind of stem cells are used to treat patients with heart attacks? Kinds of stem cells: Tissue-specific,

Overview
-
-
Sustainability: a
and the needs of other
Ecological (Carbon) Footprint the amount of
Resources
Renewable resources that are
or replenished
between Earth's resources,
are
than they
emitted and its
Nonrenewable: resources that are
quickly than they are
more

Answers

The Overview:

Sustainability is described as to the ability to meet the needs of the present without compromising the ability of future generations to meet their own needs.

Ecological  Footprint:

The ecological footprint is described as  a measure of the impact that human activities have on the environment and s measured in terms of the amount of land and water required to produce the resources we consume and to absorb the waste we generate.

Resources:

The Renewable resources are those that can be replenished and replaced naturally over time, example is  solar energy, wind energy, and timber.

The Nonrenewable resources are those that cannot be replenished or replaced once they are used up  such as fossil fuels and minerals.

More on Renewable energy ?

Renewable energy is  described as energy derived from natural sources that are replenished at a higher rate than they are consumed.

The Sunlight and wind are known example of such sources that are constantly being replenished.

In conclusion, renewable energy sources are plentiful and all around us.

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What is the force of a 3 kg skateboard accelerating at a rate of 4m/s2? Plug in the numbers: Force = mass x acceleration

Answers

Here is the answer:
Mass= 3kg
Acceleration =4m/s
Putting the formula:
F=m*s
F=3*4
F=12N( Newton is the S.l unit of force)

At the end of this process in this cell, each DNA strand is...

Completely built new with a different code

Is one half the original DNA and one half new DNA with the same code as the original strand preserved

Is one half the original DNA and one half new DNA with a different code

Answers

Answer:

Is one half the original DNA and one half new DNA with the same code as the original strand preserved

Explanation:

I am assuming the process is DNA replication.

The process of DNA replication:

step 1- the DNA double helix unwinds using an enzyme called dna helicase. Proteins hold the strands apart from each other forming a Y shape called the replication fork.

step 2- At the replication fork, enzymes called DNA polymerase move along each of the DNA strands adding complementary bases to the nitrogen bases using base pairing rules.

step 3- DNA polymerases add nucleotides to a growing double helix until all the DNA is copied

result- 2 new DNA molecules, each made of one original strand and one copied strand

how well an organism survives and reproduces in its environment can be described as its?

Answers

An organism's fitness is determined by how well it adapts to its surroundings and reproduces.

An organism's capacity for survival and reproduction in its environment is referred to as fitness. High fitness individuals are those who have environmental adaptations that allow them to live and reproduce in their environment. Fitness, in its most basic sense, refers to an organism's capacity to persist and procreate in its environment, or, less frequently, a population or species. As a result of their ability to reproduce and survive, organisms pass on their genes to the following generation. In evolutionary biology, the ability of an organism to pass on its genetic makeup to its progeny is referred to as "fitness." Being able to live long enough to reproduce and preserve the population or species is biological fitness, also known as "Darwinian" fitness.  As a result, you could say that brown beetles had a higher fitness level if they consistently produced more offspring than green beetles due to their colour.

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The above question is incomplete. Check complete question below -

How well an organism survives and reproduces in its environment can be described as its?

A. Fitness

B. Adaptation

C. Survival

D. Acclimatization

What is the term for the study of the physiochemical properties of drugs and how they influence the body

Answers

The study of the physiochemical properties of drugs and how they influence the body is called pharmacokinetics. This field of study explores how drugs are absorbed, distributed, metabolized, and excreted by the body. It involves analyzing the different stages that a drug goes through in the body and how those stages affect the drug's effectiveness and safety.

Pharmacokinetics involves the study of four key processes: absorption, distribution, metabolism, and excretion (ADME).

Absorption refers to the process by which a drug enters the body.

Distribution involves the transportation of the drug throughout the body.

Metabolism involves the chemical transformation of the drug by enzymes in the body.

Finally, excretion refers to the removal of the drug and its metabolites from the body.

The study of pharmacokinetics is important for understanding how drugs work and how they can be used most effectively and safely. It is used to determine the appropriate dosages of drugs, predict potential drug interactions, and identify factors that may affect the effectiveness and safety of a drug.

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Vivienne visits a botanical garden in a nearby city and sees a plant commonly called Touch-Me-Not. She touches the tip of the leaf of this plant, known as Mimosa pudica, with her finger and watches the leaves close. She later learns that chemicals trigger this reaction. Plants respond to stimuli in different ways. Read each of the words or phrases sentences that describe a kind of tropism. Drag each into the correct box.

Answers

Stem is an example of negative gravitropism. Thus the correct matches are A-4, B-1, C-3, and D-2.

What is tropism?

A tropism is a phenomenon, which indicates the growth or turning movement of an organism, usually a plant, in response to an environmental condition. Types of tropism are shown by the parts of plants.

The phrases with the types of tropism are matched below

Stem is an example of positive gravitropism as the stem moves in an upward direction.The root is an example of negative gravitropism as it moves in a downward direction.Coils around any object it touches are an example of thigmotropism.Grows toward light are an example of phototropism.

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Your question is incomplete. The complete question would be

A. Stem is an example of a?

B. The root is an example of a?

C. Coils around any object it touches are an example of?

D. Grows toward light is an example of a?                  

Types of tropism

1. negative gravitropism.

2. phototropism.

3. thigmotropism.

4. positive gravitropism.

Which of the following is a feature of all cells?
O A. All cells have a nucleus.
O B. All cells have a rigid cell wall.
O C. All cells are spheres.
O D. All cells have a cell membrane.

Answers

The answer is a bc it’s the eight answer

All cells have a rigid cell wall is a feature of all cells. Therefore, option (B) is correct.

What are the characteristics of cell wall?

A plant cell's cell wall is its outermost covering. It is a tough, pliable, and occasionally rigid layer that provides the cell with structural support and protection. There is no cell wall in animal cells.

Plant cells' tensile strength and resistance to mechanical and osmotic stress are provided by the cell wall, which encloses the plasma membrane. Additionally, it permits the development of turgor pressure, or the pressure of the contents of the cell against the cell wall.

The cell's interior contents are kept separate from the outside environment by the cell wall. It also gives the cell and its organelles shape, support, and protection. However, only a few prokaryotic organisms, eukaryotic plants, and fungi contain this cellular component.

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What was an impact of the industrial revolution in Great Britain Ed has 4 cards.There is a number on each card.12615?The mean of the 4 numbers on Ed's cards is 10Work out the number on the 4th card. Which ordered pair is the solution to the system of equations?{y=2x154x+3y=5Responses(5, 5)begin ordered pair n 5 comma negative 5 end ordered pair(0, 6)begin ordered pair 0 comma 6 end ordered pair(4, 7) in 2017, antle inc. had acquired demski co. and recorded goodwill of $245 million as a result. the net assets (including goodwill) from antle's acquisition of demski co. had a 2018 year-end book value of $580 million. antle assessed the fair value of demski at this date to be $700 million, while the fair value of all of demski's identifiable tangible and intangible assets (excluding goodwill) was $550 million. the amount of the impairment loss that antle would record for goodwill at the end of 2018 is: Generally speaking, digital marketing targets any digital device and uses it to advertise and sell a(n) _____.ideagovernmental policyproduct or servicereligion You have chosen from among The ILIAD's three characters, Achilles, Patroclus, and Priam, which one of the three you believe to be the most courageous and honorable man. You have defined the terms "honorable" and "courageous". What makes your choice of character the most courageous? What makes your choice the most honorable? Using specific examples from the text, justify why you believe your choice is more honorable and courageous than the other two. A) Thououghly compare the three characters and B) explain in depth, and in detail, the various things your character said or did that supports him as your choice there 2 parts to the question If a company has a cost of capital of 12%, their minimum rate of return (hurdle rate) is expected to be PLEASE HELP!!!1. Read the scenario and then respond to questions A, B, and C:A few years ago, Democrats controlled the presidency and both houses of Congress. The president took advantage of the situation to pass a sweeping law that places new environmental regulations on businesses. Republicans opposed the law because of its potential to hurt the economy and cost some Americans their jobs. Their fears proved true over the next two years, angering some voters and allowing Republicans to win a slight majority in both houses of Congress.Explain how the scenario may cause legislative gridlock.Describe at least one practical option Congress has to get Republican-backed legislation passed under the circumstances described at the end of this scenario.Explain how the relationship between the executive branch and the legislative branch, as it is described at the end of this scenario, can affect the democratic process positively or negatively. Support your explanation. v = 84.304 m/sd = ?+= 24.6s Think about animal shelters. What problems do they face in the summer? Explain. Then, explain how Jeff Bennett and his group try to help shelters.Writing Tips:Write two paragraphs.Introduce the topic; group related information together.Make points with facts, definitions, and details.Use linking words and phrases (e.g., also, another, and, more, but) to connect ideas.Include an ending statement or section.Use the words adopt and volunteer, if you can. Hhv-5 infectious in pregnant women can be particular concern because this virus can be? another easy middle school question what will be the value of g if both masses are halved? Which of the following statements about Six Sigma programs is false? A. Six Sigma programs need to be overseen by personnel who have completed Six Sigma master black belt" training and executed by personnel who have earned Six Sigma "green belts" and Six Sigma "black belts." B. Six Sigma programs utilize advanced statistical methods to enable an activity or process to be performed with 99.9997 percent accuracy (equivalent to 3.4 defects/errors per million terations). C. There are two important types of Six Sigma programs"one is forA existing processes falling below specification and needingA incremental improvement and the other is for developing new processes or products at Six Sigma quality levels. D. There is evidence that Six Sigma techniques stifle innovation and creativity, particularly as concerns such creative processes as R&D and new product development which very often involve outside-the-box brainstorming and trial-and-error experimentation. E. 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