Type I topoisomerases
a) pass one strand of a DNA double helix through a transient break in its complementary strand
b) are only found in prokaryotes
c) require the energy released by ATP hydrolysis to function
d) do not change the linking number of a supercoiled DNA

Answers

Answer 1

Type I topoisomerases pass one strand of a DNA double helix through a transient break in its complementary strand. This process helps to relieve the tension and twisting of the DNA molecule.

Type I topoisomerases are enzymes that are involved in the relaxation of DNA supercoiling. They achieve this by introducing transient breaks in one strand of the DNA double helix, allowing the other strand to pass through the break. Unlike Type II topoisomerases, Type I topoisomerases do not require ATP hydrolysis to carry out their function.

Instead, they utilize the energy stored in the DNA itself to catalyze the relaxation process. Additionally, Type I topoisomerases do not change the linking number of a supercoiled DNA molecule, as they only operate on one strand at a time.

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Related Questions

what is a turgid cell

Answers

Answer:

turgid refers to cells or tissues that are swollen from water uptake. Many cell types in many different organisms can become turgid due to water uptake. Some cells will lyse, or split open if they become too turgid.

Answer:

Explanation: turgid refers to cells or tissues that are swollen from water uptake. Many cell types in many different organisms can become turgid due to water uptake. Some cells will lyse, or split open if they become too turgid.

Why do I still need the paper that I got out from mental health?

Answers

Answer:

Because it is important that you still have the paper for future reference to show that you have passed your mental health classes and do not have to take them again.

Answer:

If you didn't have the paper how would people know that you did officially get out of mental health? Also it shows that you were once in a mental health

Hope this helps!

The process of converting the "language" of mRNA into the "language" of proteins is called *
A - translation
B - transcription
C - mutation
D - active transport

Answers

A is the correct answer

what is the correct pairing of neurotransmitters in the parasympathetic division of the autonomic nervous system?

Answers

The correct pairing of neurotransmitters in the parasympathetic division of the autonomic nervous system is that both release ACH.

What is ACH?


Acetylcholine inside the autonomic nervous system. The neurotransmitter in preganglionic sympathetic and parasympathetic neurons of the autonomic nervous system is called acetylcholine (ACh).

The heart, lungs, upper gastrointestinal tract, and sweat glands all have muscarinic acetylcholine receptors on their peripheral nerve systems.

The central and peripheral nervous systems depend on acetylcholine, a sort of chemical messenger or neurotransmitter, to function properly. It aids in learning, memory, and attention as well as the control of muscular motion and autonomic bodily processes.

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The majority of the human body is made up of molecules that contain H,
C, O, N, and P. In your own words why is a diet of only carbohydrates insufficient for long
term survival?

Answers

Answer:

In the absence of carbohydrates in the diet, your body will convert protein (or other non-carbohydrate substances) into glucose, so it's not just carbohydrates that can raise your blood sugar and insulin levels. If you consume more calories than you burn, you'll gain weight.

Help me please- will mark brainliest

Help me please- will mark brainliest

Answers

Answer:

The scale is same.

Explanation:

The scale of nuclear fusion reaction on earth  is the same as compared to fusion reactions that is happening in the sun because both reactions produces the same product i. e. energy and heat etc and both are occurring naturally. Due to large size of the sun, huge number of nuclear fusion reactions occur ac compared to the earth which is smaller in size so the scale of both nuclear fusion reactions are the same but vary in numbers.

Can the following chemical equation occur on its own?
CH4 + O2 --> FeO2 + CO2 + H2O

Answers

Answer:

No

Explanation:

This is the word equation

Methane + oxygen - - - > iron oxide + carbon dioxide + water

The equation is missing some elements as the left side has no iron but right side has an iron oxide.

Therefore this equation can not happen on its own because its not balanced

HELP I NEED HELP ASAP
HELP I NEED HELP ASAP
HELP I NEED HELP ASAP
HELP I NEED HELP ASAP

Nitrogen is a NUTRIENT needed by plants for growth. Nitrogen is naturally cycled into the soil where it is rapidly absorbed by plants. What would a farmer MOST likely do to replenish nitrogen that was depleted from the soil?

A. Use water that is enhanced with phosphates.
B. Add fertilizer to the soil to provide a source of nitrogen.
C. Use genetically altered crops that fix their own nitrogen.
D. Add bacteria to the soil in order for the crop to grow stronger roots.

Answers

Answer:

c

Explanation:

add fertilizer to the soil to provide a source of nitrogen.

Answer:

b

Explanation:

Add fertilizer to the soil to provide a source of nitrogen.

which came first the chicken or the egg (this is for a school asignment i promise)

Answers

Answer:

fs the chicken

Explanation:

Answer:

two birds that weren't really chickens created a chicken egg, and hence, we have an answer: The egg came first, and then it hatched a chicken.

Explanation:

1.
The fox population in a certain region has an annual growth rate of 5 percent per year. It is estimated that the population in the year 2000 was 23500 . (a) Find a function in the form \( P(t)=a b^{t}

Answers

The fox population can be modeled using an exponential growth function of the form P(t) = ab^t, where P(t) represents the population at time t, a is the initial population, b is the growth factor, and t represents the number of years.

In this case, the population in the year 2000 was given as 23500. We can use this information to find the values of a and b in the exponential growth function. Since the population has an annual growth rate of 5 percent, the growth factor (b) would be 1 + growth rate = 1 + 0.05 = 1.05.

To find the value of a, we substitute the given population value for the year 2000 into the exponential growth function: P(0) = ab^0 = a(1.05)^0 = a. Therefore, a = 23500.

Now we have the values of a and b, and the exponential growth function for the fox population becomes P(t) = 23500 * (1.05)^t, where t represents the number of years since the year 2000.

This function can be used to estimate the fox population for any given year after 2000 by substituting the desired value of t into the equation.

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the enzyme reverse transcriptase can make a dna copy of an rna strand. therefore, this enzyme is a(n)?

Answers

RNA viruses called retroviruses have the reverse transcriptase enzyme inside of them.

RNA can be transformed into DNA by reverse transcriptase, which can then be incorporated into the chromosome of the host cell. An enzyme found in the genetic material of retroviruses called reverse transcriptase, also known as RNA-directed DNA polymerase, is responsible for facilitating the transcription of retrovirus RNA (ribonucleic acid) into DNA (deoxyribonucleic acid). The hybrid's RNA strand is then degraded by reverse transcriptase, also known as RNase H. Then, double-stranded DNA is created using the single-stranded DNA as a template (cDNA). Many different creatures, including viruses, bacteria, mammals, and plants, have been shown to have reverse transcriptases. As a result, complementary DNA is created when an RNA template is used to create DNA through reverse transcription.

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An active transport process by which a vesicle moves a large substance out of the cell is known as __________.

osmosis
endocytosis
exocytosis
diffusion

Answers

Answer:

I'm pretty sure it is exocytosis. Because exocytosis transports vesicles out of the cell through the plasma membrane. Remember it as "exo" = exit.

Answer:

C. Exocytosis

Explanation:

The first thing we notice is that the question says "active transport". Looking at the answer choices, we see that "osmosis" and "diffusion" are options.

However, remember that osmosis (the diffusion of water from high to low concentration) and diffusion (the movement of particles from high to low concentration) are both passive transport; in other words, they don't require an input of energy. So eliminate them.

Now look at endocytosis and exocytosis. "Endo" means "inner", so "endocytosis" means the cell is engulfing a substance and bringing it inside. However, we want the process where a substance is moved out.

"Exo" means "out", so "exocytosis" means to expel something. That matches here, so our answer is C.

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Describe the functions of the main organs and systems in plants and animals and relate to this their structure 1)vill in the stomach of the digestive system

Answers

Villi are the tiny hair-like projections that line the inside of the small intestine. They contain blood vessels and help absorb nutrients.

These are slender vascular projections that increase the surface area of the membrane.

These project into the intestinal cavity, greatly increasing the surface area for food absorption and adding digestive secretions.

PLEASE HELP ME I'LL MAKE YOU BRAINLIEST!!!!!!!!!! Lichens can best be described by which of the following? a) autotrophic organisms and fungi in a mutualistic relationship b) photosynthesizing fungi that can live in harsh environment conditions c) saprophytic fungi that secretes acids to grow on and colonize rocks d) two heterotrophic fungi species that thrive on nutrients from the air

Answers

Answer:

a) autotrophic organisms and fungi in a mutualistic relationship

Explanation:

A lichen "is a composite organism that arises from algae or cyanobacteria living among filaments of multiple fungi species".

It is cyanobacteria + fungi, so it has to be two separate groups, and both cannot be fungi.

Your question has been heard loud and clear.

answer is option C , lichens do colonize on rocks most of the time , this is because they really are saprophytic fungi , that secrete acids to melt and make the rocks suitable for growing on.

Use the phylogenetic tree to the right to choose the true statement below.

Answers

The true statement based on the phylogenetic tree is: "Ray-finned fish evolved before sharks."

In the given phylogenetic tree, the branches representing ray-finned fish and sharks originate from a common ancestor.

However, the branch representing ray-finned fish diverges earlier in evolutionary history compared to the branch representing sharks. This indicates that ray-finned fish appeared before sharks in the evolutionary timeline.

Phylogenetic trees illustrate the evolutionary relationships between different species or groups of organisms. The branching patterns in the tree show the common ancestry and divergence of different lineages.

By analyzing the structure of the phylogenetic tree, we can infer the relative timing of evolutionary events and the relationships between different groups of organisms.

In this case, the phylogenetic tree indicates that ray-finned fish evolved before sharks, suggesting that ray-finned fish have a longer evolutionary history and are more ancient than sharks.

It is important to note that this statement does not provide information about the relationship between crocodiles, amphibians, primates, rodents, rabbits, and other groups mentioned in the given options.

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Question

Use the phylogenetic tree to the right to choose the true statement below.

Crocodiles are more closely related to amphibians than to primates.

A. Ray-finned fish evolved before sharks.

B. Rodents and rabbits are most closely related to primates.

C. Amphibians are more closely related to ray-finned fish than to primates.

The producers represent the second trophic level.
True or false

Answers

False producers are on the first level
Herbivores I believe would be on the second level

What cells of the epidermis function as phagocytes of the immune system?.

Answers

Langerhans cells are a type of phagocyte found in the epidermis of the skin. They play an important role in the immune system by detecting and responding to foreign invaders while also maintaining tolerance to self-antigens.

Langerhans cells function as phagocytes of the immune system. The epidermis, or outermost layer of skin, serves as the first line of defense against harmful stimuli and pathogens.

It consists of several types of cells that work together to protect the body from damage and infection.

Langerhans cells are dendritic cells that reside in the epidermis of the skin and act as antigen-presenting cells.

They are able to capture and process antigens and then present them to T cells to initiate an immune response.

They play an important role in the skin's immune defense by detecting and responding to foreign invaders, such as bacteria, viruses, and fungi.

Langerhans cells are also involved in maintaining tolerance to self-antigens and preventing autoimmunity.

They have the ability to induce T cell anergy or tolerance, which helps prevent the immune system from attacking normal, healthy cells.

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would the ability to hydrolyze urea affect microbial pathogenicity? explain how urease activity might be considered a virulence factor.

Answers

Yes, the ability to hydrolyze urea affects microbial pathogenicity. Urease activity is considered a virulence factor. Let us explain how urease activity might be considered a virulence factor. Urea is a nitrogen-rich compound. Bacteria need nitrogen for protein synthesis, and urea is a source of nitrogen.

Bacteria that can break down urea have an advantage over bacteria that cannot. Urease is an enzyme that breaks down urea into ammonia and carbon dioxide. The ammonia that is generated in the process makes the environment around the bacterium more basic.

This can be used by the bacterium to neutralize acidic environments created by the host or other competing bacteria. The bacterium can thus grow in an environment that might not otherwise be conducive to its survival or multiplication. The ability to break down urea can make the bacteria more pathogenic.

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1. What does each unit on the y-axis represent?
Please please help

1. What does each unit on the y-axis represent? Please please help

Answers

i’m pretty sure it is A

Answer:

A

Explanation:

The y axis is the vertical area and we can see 0-250-500- so on

as well as the small chunk of text saying popula-

what happens before RNA polymerase begins to work

Answers

Answer:

D. Nucleic acids attach to the bases in the DNA.

Explanation:

Transcription begins when an enzyme called RNA polymerase is added to the DNA template and begins a new chain a new chain to produce complementary RNA. During the RNA synthesis transcription takes place, then the cap and tail is added and then splicing occurs. RNA polymerase moves from the 3 'end to the template strand creating the RNA-DNA double helix or similar the base sequences. This makes a chain with each sugar by the set of bonds called phosphodiaster linkage. Then, the enzyme unwind the DNA and begins the synthesis of RNA. Therefore, D. Nucleic acids attach to the bases in the DNA.

Which sentence best describes a rattlesnake as a living system that is one
part of a more complex system?
OA. A rattlesnake can eat multiple mice in a single day.
B. A rattlesnake will shed its skin often as it grows.
C. A rattlesnake can give birth to ten young snakes at once.
OD. A rattlesnake lives in the desert with other snakes.

Answers

The statement that best describes a rattlesnake as a living system is one part of a more complex system a rattlesnake will shed its skin often as it grows. Thus, the correct option for this question is B.

What are the characteristics of the living system?

The characteristics of the living system are as follows:

They possess a high level of compartmentalization.They stimulate systematic growth and division.Living systems are known for information processing.They also conduct energy transduction.They possess a high level of adaptability.

A rattlesnake can eat multiple mice in a single day must deal with the mode of nutrition and eating plan. While giving birth to ten young snakes at once follows a reproductive pattern. Living in the desert with other snakes reveals its level of adaptation and survival.

Therefore, the statement that best describes a rattlesnake as a living system is one part of a more complex system a rattlesnake will shed its skin often as it grows. Thus, the correct option for this question is B.

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Answer: A rattlesnake lives in the desert with other snakes.

Explanation: took the test

Describe the process of thermohaline circulation. Your answer must include details on the process, where waters "sink" and "rise", time for turnover of this conveyer, and the significance of this process to global climate.

Answers

Thermohaline circulation plays a crucial role in redistributing heat globally, influencing climate patterns and regulating the transfer of carbon dioxide and other gases between the atmosphere and the ocean.

Thermohaline circulation is a process of global ocean circulation driven by differences in temperature (thermo) and salinity (haline).

It begins in the polar regions, where surface waters become cold and dense due to low temperatures. These dense waters sink and form deepwater masses.

The sinking occurs mainly in the North Atlantic and around Antarctica. The deep waters then flow towards the equator, where they gradually rise to the surface through upwelling. This circulation pattern takes around 1,000 years for a complete turnover.

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hi so i just received a death threat from +592 6034153,can someone pls help me find the identity of this person and pls put a pic of the person.​

Answers

Answer:

below

Explanation:

you can report this to the cops or a older authority. Posting a picture is a form of doxxing and can be illegal or a form of witchhunting.

which method of measuring behavior is most effective at directly studying brain activity?

Answers

The most efficient approach of assessing behavior for directly examining brain activity is computed tomography (CT) scanning.

Which approach allows scientists to investigate brain anatomy the best?

Over the past two decades, functional MRI (fMRI), a type of MRI, has become the most widely used neuroimaging technology. Blood flow and oxygen levels are monitored by fMRI to detect brain activity.

What two methods of brain research show brain activity?

With the aid of cutting-edge noninvasive neuroimaging methods like EEG and fMRI, researchers may now watch brain activity while volunteers carry out different perceptual, motor, and/or cognitive tasks. The method used most frequently today to understand brain structure is fMRI. The fMRI produces images of the brain's anatomy and activity.

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during adolescence, individuals' iq scores _____, whereas their mental abilities _____.

Answers

During adolescence, individuals' IQ scores remain stable, whereas their mental abilities increase.

As adolescents grow, their cognitive abilities undergo significant changes due to various factors such as brain development, hormonal changes, and environmental influences. While IQ scores represent a snapshot of an individual's intelligence at a given time, it is important to remember that they do not capture the full spectrum of mental abilities.

Mental abilities encompass a wide range of cognitive skills, including problem-solving, reasoning, memory, and creativity. Throughout adolescence, these skills continue to mature as the brain undergoes critical growth and reorganization. Neural connections strengthen, and the brain becomes more efficient in processing information. This development is influenced by the challenges and experiences that adolescents face in their daily lives, which helps to hone their mental abilities further.

In summary, during adolescence, IQ scores tend to stabilize, reflecting a relatively consistent measure of intelligence. However, mental abilities continue to evolve and mature as the brain undergoes significant developmental changes. This ongoing development allows adolescents to acquire a broader range of cognitive skills and adapt to the increasing demands of their environment.

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where does the o2 released during photosynthesis come from?

Answers

The oxygen (\(O_{2}\)) released during photosynthesis comes from the water molecule (\(H_{2}O\)).

Light energy splits water molecules into oxygen, hydrogen ions (H+), and electrons in chloroplast thylakoid membranes during photosynthesis. Photolysis (photooxidation) involves several steps:

Chlorophyll and other chloroplast pigments absorb light energy.

Electron Transport: Light energy energises chlorophyll electrons. Electron transport chains in the thylakoid membrane transfer these energised electrons.

Water Splitting: The electron transport chain splits water molecules into O2, H+, and electrons. Water-splitting complex or photosystem II catalyses this process.

Photosynthesis releases oxygen from chloroplasts. It is released into the atmosphere for oxygen-dependent species.

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The oxygen released during photosynthesis comes from the splitting of water molecules in the light-dependent reactions.

During photosynthesis, plants convert carbon dioxide (CO2) and water (H2O) into glucose (C6H12O6) and oxygen (O2) using sunlight and chlorophyll. The oxygen released during photosynthesis comes from the splitting of water molecules. This process is known as photolysis or light-dependent reactions.

In the thylakoid membranes of the chloroplasts, light energy is absorbed by chlorophyll, which excites electrons. These excited electrons are then passed through a series of electron carriers, creating a flow of electrons. As a result, water molecules are split into oxygen, hydrogen ions (H+), and electrons.

The oxygen molecules are released as O2 gas, while the hydrogen ions and electrons are used in the subsequent steps of photosynthesis to produce ATP and NADPH, which are energy-rich molecules used in the synthesis of glucose.

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a plasmid that can replicate in e. coli and pseudomonas is most likely a/an

Answers

A plasmid that can replicate in both E. coli and Pseudomonas is most likely a broad-host-range (BHR) plasmid.

BHR plasmids are capable of replicating in multiple bacterial species, making them highly valuable tools in genetic engineering and biotechnology. These plasmids have a unique ability to survive in diverse bacterial environments, making them ideal for use in recombinant DNA technology. BHR plasmids are often used to transfer genetic material between bacterial species, and they are especially useful in environmental microbiology research where different bacterial species are present in the same ecosystem. The ability of BHR plasmids to replicate in multiple bacterial hosts is due to their unique genetic features, including genes that promote plasmid stability, efficient replication, and compatibility with different bacterial hosts. In summary, a plasmid that can replicate in both E. coli and Pseudomonas is most likely a broad-host-range plasmid, which is an essential tool in genetic engineering and biotechnology.

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A young goat has downward-curved horns. Its father has upward-curved horns while its mother has downward-curved horns. Which of these statements is the explanation?

Answers

A young goat has downward-curved horns. One copy of the gene for horn shape was passed down to the young goat from its father and one copy from its mother is the explanation.

A ratio of dominant to recessive traits is the result of the gene combination from the parents, as stated by Mendel's second law of inheritance, which states that a pair of traits segregate independently of another pair during gamete formation. In phenotype sharing, the offspring will only exhibit the dominant trait when parents with required traits are crossed together. This suggests that the dominant mother and not the dominant father passed on the horn-shaped gene to the young goat.

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According to the food and drug administration (fda) pregnancy risk categories, the nurse identifies which category of drugs may cause slight risks to the fetus?

Answers

Category B drugs may cause slight risks to the fetus according to the FDA pregnancy risk categories.

These drugs have been tested on animals and have not shown adverse effects on the fetus, but there are limited human studies available. The potential benefits of these drugs may outweigh the possible risks in pregnant women. Category B drugs are considered relatively safe during pregnancy, but caution is still advised. Healthcare providers carefully evaluate the individual circumstances of each pregnant woman before prescribing these drugs. It's important to note that no drug is completely risk-free during pregnancy, and potential risks should be weighed against the benefits of treatment. The healthcare provider and the pregnant woman should engage in a thorough discussion to make an informed decision about the use of Category B drugs during pregnancy.

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. What causes a hurricane to form


will give brainliest to smartest answer

Answers

Answer:

For one to form, there needs to be warm ocean water and moist, humid air in the region. When humid air is flowing upward at a zone of low pressure over warm ocean water, the water is released from the air as creating the clouds of the storm. As it rises, the air in a hurricane rotates.

Explanation:

In short pressure zones over warm ocean

Answer:

When warm moist air over the water rises, it is replaced by cooler air.

The cooler air will then warm and start to rise.

If there is enough warm water, the cycle will continue and the storm clouds and wind speeds will grow causing a hurricane to form.

Explanation:

I used to live in SW. Fl

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James has just turned 35 years old, and he has decided it is time to plan seriously for his retirement. On each birthday, beginning in one year and ending when he turns 65, he will save $10,000 in an RRSP account. If the account earns 10% per year, how much will James have saved at age 65. I want a legit answer. Tamara attends a cycling class that starts at 6:00. The class lasts 45 minutes. What time does class end? i'll give you brainliest !! please help 10. Mark and Matthew are new to financial analysis. They found that the debt ratio of DDL is 0.5, what is the debt-equity ratio of the same company? Ignore leases.Answer:11. At an opportunity cost of capital of 10%, which of the following cash flow profiles would you prefer?A$ 500 Year 1$300 Year 2$100 Year 3B100 Year 1300 Year 2500 Year 3Year 1300 Year 1300 Year 2300 Year 3D Any of the above as they all add up to $900a. Cash flow profile Cb. Cash flow profile Ac. Cash flow profile Bd. I am indifferent because the add to $900 A.Who was the first english mathematician who first used the modern symbol of equality in 1557?(To get the answer,compute the sums of the given exercises below.Write the letter of the problem correponding to the answer found in each box at the bottom). A tax imposed on the sellers of a good will lower the ____ and ____ the equilibrium quantity. a.price paid by buyers: lower b.price paid by buyers: raise c.effective price received by sellers: lower d.effective price received by sellers: raise To eliminate wordiness, we write the sentences in the ___________________.*active voicepassive voice What signal word or phrase lets the reader know how texting and talking on ones cell phone while driving are alike?becausesimilarlyone suchin summary True of False: When finding percent change, if your percent is negative, that means that the percent change is decreasing.True or False Samantha has $600 to spend at a bicycle store for some new gear and biking outfits.Assume all prices listed include tax. She buys a new bicycle for $392.25. She buys 3 bicycle reflectors for $7.01 each and a pair of bike gloves for $34.96.She plans to spend some or all of the money she has left to buy new biking outfitsfor $75.88 each.Write and solve an inequality which can be used to determine x, the number ofoutfits Samantha can purchase while staying within her budget.Inequality: According to the feedback loop, what does high blood sugar promote. Carla Vista Company had $212,200 of net income in 2021 when the selling price per unit was $151, the variable costs per unit were $95, and the fixed costs were $571,800. Management expects per unit data and total fixed costs to remain the same in 2022. The president of Carla Vista Company is under pressure from stockholders to increase net income by $84,000 in 2022. (a) Compute the number of units sold in 2021. units ||| (b) Compute the number of units that would have to be sold in 2022 to reach the stockholders' desired profit level. units (c). Assume that Carla Vista Company sells the same number of units in 2022 as it did in 2021. What would the selling price have to be in order to reach the stockholders' desired profit level? New selling price $ Which answer correctly describes the transformation from the preimage to theimage?a translation 10 units left and 8 units downa reflection over the x-axisa translation 10 units right and 8 units upa rotation of 180a reflection over the y-axis Giving 10 points and brainliest for correct answer to answer this question, complete the lab using the information below. you have been asked to perform administrative tasks for a computer that is not a member of a domain. to increase security and prevent unauthorized access to the computer, you need to configure specific password and account lockout policies. in this lab, your task is to use the local security policy to configure the following password and account lockout policies: configure password settings so that the user must: cycle through 10 passwords before reusing an old one. change the password every 90 days. keep the password at least 14 days. create a password at least eight characters long. create a password that meets complexity requirements, such as using uppercase letters, lowercase letters, numbers, or symbols. configure the account lockout policy to: lock out any user who enters five incorrect passwords. unlock an account automatically after 60 minutes. configure the number of minutes that must elapse after a failed logon attempt to 10 minutes. Describe what is shown in the graph below D. Have you ever been on a holiday trip or travelled to different places? Mention the hotspots, points of interest, etc. Share your experiences with your friends. What is the main goal of a storys protagonist for every left handed person there are about 4 right handed people . if there are 30 students in a class president the number of students who are right handed how do boas and pythons kill their prey